The European Chemicals Agency (ECHA) has recently provided updated guidance giving advice on how to use non-animal test methods. The guidance takes into account the recently changed REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) information requirements, which made non-animal testing the default method for skin corrosion/irritation, serious eye damage/eye irritation and skin sensitisation. In addition, the guidance introduces a new possibility to use a weight-of-evidence approach for acute toxicity.
Source: https://echa.europa.eu/