OLIGOs such as ASOs, siRNAs and other mRNA-targeted therapeutics are impacting patients daily. To further expand the scope of these drug modalities the field is exploring new ways to formulate and distribute the cargo to improve the reach of additional disease-relevant tissue. Efforts include various ways of targeting the delivery, for example by conjugating the cargo to functional groups that interact with specific cell types. This is one area in which developments interplay with the field of chemical biology, where the aim is to exploit chemistry for the purpose of understanding and manipulating biology. With the recent announcement of the latest Nobel Prize in Chemistry for bio-orthogonal chemistry and click chemistry, there is more reason than ever to discuss the next advancements that will impact our understanding of and man-made changes to biology. This meeting will explore these opportunities and challenges in six focus areas as outlined at the web page (https://www.elrig.org/portfolio/elrigs-therapeutic-oligos-european-chemical-biology-symposium-2023/).